Liver Function Tests of COVID-19 Patients‎

Liver Function Tests of COVID-19 Patients‎


  • Ayoub Tavakolian Department of Emergency Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, ‎Iran.‎
  • Mona Gerayli ‎1‎ Student Research Committee, Sabzevar University of Medical Sciences, Sabzevar, Iran.


Coronavirus, COVID-19‎, Length of hospitalization‎


Objectives: This study aimed to evaluate liver injuries in hospitalized COVID-19 patients.

Methods: This was a prospective study. Patients who were admitted to Vasi Hospital of Sabzevar University of Medical Sciences between April 2019 and September 2019 had a definite laboratory diagnosis of COVID-19. Enzymes and parameters of ALT, AST, ALP, total and direct bilirubin, and recovery status. The respiratory rate at admission was considered an outcome of COVID-19 severity.

Results: Total number of 100 patients (50 male/50 female), with a mean age of 54±18.01 years (ranging from 18 to 86 units/liter) were evaluated. Respiratory rate was significantly associated with direct bilirubin (r=0.433; P<0.001), with a positive correlation. Other findings were non-significant (P>0.05). Thirty-two patients had a partial recovery, 49 had a complete recovery and eighteen percent died. There was no statistically significant relationship between the condition of the COVID-19 patients and the levels of total bilirubin, direct bilirubin, Alkaline Phosphatase (ALP), serum glutamic-oxaloacetic transaminase (SGOT), Serum Glutamic Pyruvic Transaminase (SGPT) (P>0.05). The results of the independent t-test showed that in patients whose respiratory rate was less than 20 or higher than 20, male or female patients, and less than 5 or more than 5 days hospitalization, there were no statistically significant differences in the amount of bilirubin, direct bilirubin, ALP, SGOT, SGPT (P>0.05).

Conclusion: Only direct bilirubin was positively correlated with respiratory rates and no other comparisons were significant.  Patients with true dyspnea should be assessed more closely.



Sabzevar University of Medical Sciences

Conflicts of interest:


Authors' contributions: 

AT and MG wrote the study protocol, collected datasets, performed statistical analyses, and wrote the manuscript.

Acknowledgments ‎


Ethical considerations

The study was approved by the Institutional Review   Board of   Sabzevar University of   Medical Sciences with the code IR.MEDSAB.REC.1399.118


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How to Cite

Tavakolian, A., & Gerayli, M. (2023). Liver Function Tests of COVID-19 Patients‎. Updates in Emergency Medicine. Retrieved from



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