TY - JOUR AU - Tavakolian, Ayoub AU - Gerayli, Mona PY - 2023/03/01 Y2 - 2024/03/29 TI - Liver Function Tests of COVID-19 Patients‎ JF - Updates in Emergency Medicine JA - Update in Emerg Med VL - 3 IS - 1 SE - Research Study DO - UR - http://uiemjournal.com/index.php/main/article/view/29 SP - AB - <p><strong>Objectives:</strong> This study aimed to evaluate liver injuries in hospitalized COVID-19 patients.</p><p><strong>Methods:</strong> This was a prospective study. Patients who were admitted to Vasi Hospital of Sabzevar University of Medical Sciences between April 2019 and September 2019 had a definite laboratory diagnosis of COVID-19. Enzymes and parameters of ALT, AST, ALP, total and direct bilirubin, and recovery status. The respiratory rate at admission was considered an outcome of COVID-19 severity.</p><p><strong>Results:</strong> Total number of 100 patients (50 male/50 female), with a mean age of 54±18.01 years (ranging from 18 to 86 units/liter) were evaluated. Respiratory rate was significantly associated with direct bilirubin (r=0.433; P&lt;0.001), with a positive correlation. Other findings were non-significant (P&gt;0.05). Thirty-two patients had a partial recovery, 49 had a complete recovery and eighteen percent died. There was no statistically significant relationship between the condition of the COVID-19 patients and the levels of total bilirubin, direct bilirubin, Alkaline Phosphatase (ALP), serum glutamic-oxaloacetic transaminase (SGOT), Serum Glutamic Pyruvic Transaminase (SGPT) (P&gt;0.05). The results of the independent t-test showed that in patients whose respiratory rate was less than 20 or higher than 20, male or female patients, and less than 5 or more than 5 days hospitalization, there were no statistically significant differences in the amount of bilirubin, direct bilirubin, ALP, SGOT, SGPT (P&gt;0.05).</p><p><strong>Conclusion:</strong> Only direct bilirubin was positively correlated with respiratory rates and no other comparisons were significant.  Patients with true dyspnea should be assessed more closely.</p><p><strong>Declarations: </strong></p><p><strong>Funding:</strong></p><p>Sabzevar University of Medical Sciences</p><p><strong>Conflicts of interest: </strong></p><p>None</p><p><strong>Authors' contributions:</strong> </p><p>AT and MG wrote the study protocol, collected datasets, performed statistical analyses, and wrote the manuscript.</p><p><strong>Acknowledgments</strong> ‎</p><p>None.</p><p><strong>Ethical considerations</strong></p><p>The study was approved by the Institutional Review   Board of   Sabzevar University of   Medical Sciences with the code IR.MEDSAB.REC.1399.118</p> ER -