Nausea Management after Analgesia with ‎Ketorolac and ‎Morphine: Case Study of Septorhinoplasty Patients

Mojtaba Sohrabpour; Mojtaba Ghaedi; Seyed Ebrahim  Sadeghi; Reza Sahraeai; Mohammad Sadegh  Sanie Jahromi; Navid Kalani

Nausea Management after Analgesia with ‎Ketorolac and ‎Morphine: Case Study of Septorhinoplasty Patients

Authors

Mojtaba Sohrabpour Assistant Professor of Otorhinolaryngology, Head and Neck Surgery, Department of Otorhinolaryngology, Vali Asr Hospital, Fasa University of Medical Science, Fasa, Iran.
Mojtaba Ghaedi Assistant Professor of Plastic Surgery, Department of Surgery, Jahrom University of Medical Sciences, Jahrom, Iran.
Seyed Ebrahim Sadeghi Department of Anesthesiology, Shiraz University of Medical Sciences, Shiraz, Iran.
Reza Sahraeai Department of Anesthesiology, Jahrom University of Medical Sciences, Jahrom, Iran.
Mohammad Sadegh Sanie Jahromi Department of Anesthesiology, Jahrom University of Medical Sciences, Jahrom, Iran
Navid Kalani Department of Anesthesiology, Jahrom University of Medical Sciences, Jahrom, Iran.

Keywords:

ketorolac, morphine, postoperative nausea, septorhinoplasty

Abstract

Introduction: Patients undergoing plastic surgery are at increased risk for PONV. This ‎complication may have disastrous effects such as hematoma or suture disruption and destroy ‎the desired aesthetic result. The present study was conducted with the aim of investigating and ‎comparing the rate of postoperative nausea in patients receiving ketorolac and morphine, ‎and undergoing septorhinoplasty surgery.‎

Materials and methods: This study is a double-blind randomized clinical trial that was ‎conducted during a six-month period from March ‎‏2021‏‎ to August ‎‏2022‏‎ in 180 patients referred ‎to the operating room of Motahari Hospital in Jahrom city who underwent septorhinoplasty ‎surgery. , Done. Patients were randomly divided into three groups: 15 mg/kg morphine and 30 ‎and 60 mg ketorolac. Information collection tools include; Age, gender and degree of nausea ‎after the operation.‎

Results: The studied groups are similar in terms of age, sex and demographic characteristics. In ‎terms of nausea, Fisher's statistical test showed that patients in the group receiving 6 mg of ‎morphine felt nausea, which was statistically significant (P=0.035). No person in the group ‎receiving ketorolac 60 mg and ketorolac 30 mg experienced nausea.‎

Conclusion: Based on the results of the present study, the use of doses of 30 and 60 mg of ‎ketorolac, unlike morphine, did not cause nausea in septorhinoplasty patients receiving this ‎drug.‎

Acknowledgment:‎

We would like to thank the Clinical Research Development Unit of Peymanieh Educational and ‎Research and Therapeutic Center of Jahrom University of Medical Sciences for providing facilities for ‎this work.‎

Authors Contributions:‎

Seyed Ebrahim Sadeghi contributed to the data analysis and interpretation. Reza Sahraeai and Mohammad Sadegh Sanie Jahromi provided critical feedback and helped to shape the research. Navid Kalani assisted with data collection and analysis. Mojtaba Ghaedi contributed to the literature review and writing of the manuscript. Mojtaba Sohrabpour oversaw the project and provided guidance throughout the research process.‎

Conflict of interest:‎

There are no conflicts of interest in this study.‎

Research funding: None.

Ethical consideration:

This study was approved by ethics in research committee with a code of: IR.JUMS.REC.1400.043

Data availability: ‎

No data are available for this review study.

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Nausea Management after Analgesia with ‎Ketorolac and ‎Morphine: Case Study of Septorhinoplasty Patients