A Prospective Study of Lung Lesions in COVID-19 ‎Survivors

A Prospective Study of Lung Lesions in COVID-19 ‎Survivors


  • Behzad Aminzadeh Department of Radiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.‎
  • Morteza Talebi Doluee Department of Emergency Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.‎
  • Mona Maftouh Department of Radiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.‎
  • Mahnaz Amini Lung Diseases Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.‎
  • Farrokh Seilanian Toosi Department of Radiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.‎
  • Maryam Emadzadeh Department of Community Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.‎
  • Saeid Eslami Department of Medical Informatics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Ahmadreza Tavassoli Department of Radiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.‎


COVID-19‎, Lung Diseases, Spiral Computed Tomography, Aftercare


Background: We investigated chest Computed tomography (CT) findings of patients with COVID-19 admitted to Intensive Care Unit (ICU) and wards two months after recovery.

Objective: We evaluated the relationship between 2-month follow-up CT findings with the lung involvement severity in their first CT scan upon admission and with the medications administered for them.

Methods: Forty-six COVID-19 patients were enrolled, including 23 admitted to the wards and 23 ICU admitted ones. A Chest CT scan was performed and the initial involvement score was recorded. Patients were recalled two months after recovery for follow-up CT. The prevalence of abnormalities in follow-up CT was compared between the two groups. Also, we evaluated the relationship between the first CT score and medications with follow-up CT involvement.

Results: Our results indicated that two-month follow-up CT abnormalities were found in 91.3% of ICU patients and in 47.8% of ward-admitted ones. The ground glass opacity(GGO) was the commonest (84.4%) abnormality of studied cases after two months, followed by reticulation(65.6%), and atelectasis(43.8%). The presence of abnormalities was related to age (P=0.002), initial total lung involvement scores (TLI) (P=0.007), and admission to ICU versus wards (P=0.001). ROC analysis showed that a TLI score equal to 11 had 65% sensitivity and 72% specificity to predict the presence of abnormalities in follow-up CT (P=0.007). We did not find any relationship between the administered medications and follow-up CT abnormalities, except for meropenem. 

Conclusions: Two-month follow-up chest CT abnormalities are significantly more frequent in older patients, ICU-admitted survivors, and those with a higher TLI score in the initial chest CT scan.


Funding: The study was supported by the Vice-Chancellor of Research, Mashhad University of Medical Sciences, Mashhad, Iran under thesis research number 990061.

Conflicts of interest:  None.

Acknowledgments: We would like to express our gratitude to the Clinical Research Development Unit of Ghaem Hospital.‎

Ethical considerations: The ethical protocol of this study was based on principles of the Declaration of Helsinki ‎‎(IR.MUMS.REC.1399.063). (webpage of ethical approval code is: ‎https://ethics.research.ac.ir/EthicsProposalView.php?id=127653 )‎


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How to Cite

Aminzadeh, B., Talebi Doluee, M., Maftouh, M., Amini, M., Seilanian Toosi, F., Emadzadeh, M., Eslami, S., & Tavassoli, A. (2023). A Prospective Study of Lung Lesions in COVID-19 ‎Survivors. Updates in Emergency Medicine, 2(2). Retrieved from http://uiemjournal.com/index.php/main/article/view/32



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